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Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats. McLaughlin and colleagues were the first to reveal the role of dynorphins and KOR in transducing the effects of social stress An important task for future research will be to explore emotional-like responses in the context of more sophisticated models of addictive-like behaviors. Chronic exposure to drugs of abuse, as well as prolonged abstinence from these drugs, is strongly associated with lowered mood and a negative affective state. The effect of this local manipulation on ultrasonic vocalizations was not assessed; however, it is likely that CeA KOR signaling may contribute to negative affect following chronic ethanol exposure.

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Behav Brain Res The authors thank Dr. Pharmacol Ther 2: Journal List Front Psychiatry v. Paramount [France] Universal [United States]. Other investigators used electrophysiology and immunohistochemistry to identify KOR-expressing neurons. In the near future, such approaches will likely aid in the development of antidepressants acting as KOR antagonists and devoid of potentially associated adverse effects e.